Artichoke leaf derives from the common globe artichoke, a widely consumed vegetable cultivated by both the early Greeks and Romans. The leaves of artichoke contain a primary compound known as cynarin, which among its other properties improves liver and gall bladder function, and lowers serum cholesterol. Artichoke has long been used as a digestive. Artichoke leaf extract is widely used alone or in association with other herbs for embittering alcoholic and soft drinks and to prepare herbal teas or herbal medicinal products. Some of the research with artichoke extract is listed below. It appears that this supplement has many health benefits. Artichoke leaf extract has been tested in heartburn, also known as dyspepsia. Artichoke leaf has also been tested in irritable bowel syndrome and high cholesterol. Artichoke extract is available in a number of concentrations and extract potencies. Herbal Powers Ingredients has artichoke extract as 5 percent cyananine.