Synonyms: 2-Ketoglutaric acid alpha-Ketoglutaric acid 2-Oxoglutarate 2-Oxoglutaric acid
Molecular formula C5H6O5
Molar mass 146.11 g/mol
Melting point 113.5
CAS number [328-50-7]
Solubility in THF, ethanol, methanol THF 2.33 M, ethanol 1.94 M, methanol 3.75 M
α-Ketoglutaric acid is one of two ketone derivatives of glutaric acid. (The term "ketoglutaric acid," when not further qualified, almost always refers to the alpha variant. β-Ketoglutaric acid varies only by the position of the ketone functional group, and is much less common.)
Its anion, α-ketoglutarate (also called oxo-glutarate) is an important biological compound. It is the keto acid produced by de-amination of glutamate, and is an intermediate in the Krebs cycle.