Name: Acetyl-L-carnitine hydrochloride
Synonyms: (R)-3-Acetoxy-4-(trimethylammonio)butyrate hydrochloride; R(-)-2-Acetyloxy-3-carboxy-N,N,N-trimethyl-1-propanaminium chloride; Levacecarnine hydrochloride
Molecular Formula: C9H17NO4.HCl
Molecular Weight: 239.70
CAS Number: 5080-50-2
Acetyl-L-Carnitine HCl is a natural substance present in the human body, especially in muscles, brain and sperm. Acetyl-L-Carnitine HCl is involved in many essential metabolic processes. Besides the function of L-Carnitine, Acetyl-L-Carnitine HCl has some special functions including benefit to dementia and memory impairment and improving male fertility and enhancing immune function.
Acetyl-L-carnitine hydrochloride is thought to increase general metabolic activity and to improve cognitive function. Acetyl-L-carnitine is a mitochondrial metabolite that facilitates the movement of fatty acids into the mitochondria for energy and is also used to generate acetyl coenzyme A.
Acetyl-L-carnitine hydrochloride has demonstrated some efficacy as a neuroprotective agent and its administration may be indicated for use in strokes, Alzheimers disease, Downs syndrome, and managing some neuropathies. Other human conditions reported to benefit from acetyl-L-carnitine administration are geriatric depression, cerebellar ataxia, type 2 diabetes, and HIV.
Acetyl-L-carnitine alone is also marketed as an anti-aging dietary supplement. It is thought that acetyl-L-carnitine may improve mental impairments in aging humans and animals through mechanisms that increase energy metabolism in the brain and enhance brain cholinergic activity through acetylcholine release. Animal studies suggest that supplemental acetyl-L-carnitine may enhance cognitive functioning by elevating nerve growth factor (NGF) levels in the brain, stabilizing cell membranes and improving synaptic morphology, and decreasing the accumulation of potentially toxic fatty acids.